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Warning to Resveratrol Supplement Buyers

Unlike most nutritional foods, hundreds of well-researched scientific studies and trials have established resveratrol's potentially critical health property as a treatment for diabetes, cancer, inflammation and immune diseases and neurological conditions. Regardless of the efficacy or efficacy of resveratrol it is clear that many people buy resveratrol as a preventative or treatment for serious medical conditions. If these consumer purchases of resveratrol are not of high quality, well-produced, their active bio compounds not only waste their money but also do not receive any benefits resveratrol can offer to improve their condition.

The criteria below are based on valid science principals and accepted standards for assessing whether supplements work like resveratrol. Standards can also be used in evaluating other supplements.

Ethical labeling

Many resveratrol providers do not disclose the exact form of resveratrol or the quantity contained in their supplements. Some call the main ingredient a "red wine complex" or "proprietary blend". Since red wine contains less than 1% of resveratrol, it seems strange that a company would use this description to label resveratrol products unless it was intended to conceal the actual ingredients in the product. Proprietary combinations can be anything but impossible to contain pure resveratrol given the high cost of resveratol compared to other ingredients.

Resveratrol is composed of two major isomers, trans-resveratrol and cis-resveratrol. Only trans-isomers are associated with health benefits. The cis isomer actually acts to reverse the effects of trans-resveratrol. Unless the seller states on the label that the product is completely trans-resveratrol, it is likely to contain one or all cis-resveratrol, that is, in order of magnitude, the less expensive form of resveratrol.

The size 0 capsule can contain about 500mg of resveratrol, if the basic ingredients are processed using pharmaceutical technology and equipment. This is the largest capsule that most people can easily swallow. Sellers who use larger capsules do so to offset the fact that they simply insert the raw extract into the capsule without the time and expense to clean and absorb the resveratrol extract. Larger capsules also allow the use of various fillers and chemicals such as silicon, magnesium stert, cellulose, and other additives. The high quality resveratrol supplements come in 0 capsules and contain no additives or fillers at all. There is no reason why you should take sand and other inactive ingredients in your supplement simply because your supplier cannot be disrupted by using advanced processing and filling technologies.

Is red wine the best source of resveratrol?

While many news on resveratrol cite red wine grapes as a source, grapevines are not a practical source of resveratrol for two important reasons. The first grape is subject to a variety of toxic chemicals in the process of cultivation. Fungicides, pesticides, chemical fertilizers and many other chemicals are sprayed directly on grape vines. Because resveratrol is derived from the skin, it is difficult to eliminate the contamination in resveratrol concentrate. The second reason wine is not a good source of resveratrol is that it is not possible to produce high-potency supplements using wine extracts. Resveratrol concentration in grape skin is too low. This is why all animal and tissue research on the health benefits of resveratrol source resveratrol is a giant plant, which grows without fertilizers or agricultural chemicals in the wild.

Capsules and packing

The capsule itself should be all vegetable like Pfizer Vcaps of clear gelatin, made from animal products. Not only are all capsules of vegetables healthy for animal consumption but they are designed to better regulate the release of active ingredients into your digestive tract when taken orally. What is the use of taking natural supplements if capsules are derived from collagen in the skin and bones of animals?

Resveratrol is very easy to reduce with oxidation and exposure to ultraviolet light. The quality additives will be protected against oxidation during manufacture through the use of a full nitrogen gas processing line. The bottles in which the supplement contains should also use inert gas to prevent oxidation during shipping. However, when the bottle is opened the oxygen is allowed to enter. If the active packaging technology is not used to protect against this damage, the product life expectancy will be very poor. An oxygen absorption system is required to capture the oxygen entering the bottle when the capsule is taken.


The appropriate dosage for trans-resveratrol is a very controversial issue, with regard to the rhetoric of resveratrol providers. The science of dosing is quite clear. Although a dose of about 100mg has emerged from several studies to have potentially important preventative effects, the consensus is that at least 250mg is needed to reach the efficacy threshold as shown in most animal and in vitro studies conducted to date. This is equivalent to the human dose used in Dr.'s study. Sinclair and many other studies. The dose recommended by most doctors for the treatment of existing conditions is between 1,000mg to 4,000mg. However, it is recommended that one consult a doctor before taking a dose above 1,000mg daily. There are no toxic or serious side effects observed in some animal and human studies where up to 5,000mg is given daily for a long time. In animal studies, doses up to 30,000mg have been tolerated with only minor adverse effects.

Natural versus synthetic resveratrol

Synthetic resveratrol can be produced using one of two methods, fermentation and chemical engineering. In the case of fermentation, yeast or bacteria are genetically modified to produce resveratrol. Chemical engineering resveratrol is made from a compound that uses organic chemicals to produce molecules. Both of these processes are full of potential traps. In the case of frequent fermentation what happens is the bacterial bit or yeast DNA used to produce resveratrol that appears in the finished material. This means that if you use this product, you are consuming a new ingredient, a compound that has never been used by humans, with potentially toxic or other unknown effects. In the case of resveratrol chemical engineering products the issue is contamination by a small amount of the chemicals used to produce synthetic resveratrol. About the typical HPLC graph of chemical engineering resveratrol will almost always be a staple on what is referred to as "unknown". These chemicals are by the product of the manufacture of substances that are not known and are assumed or are expected to be non-toxic. Furthermore, resveratrol naturally from the cuspidatum polygonum plant is known to be non-toxic and effective. Both properties have been validated for specificity of synthetic resveratrol. There is only one reason some suppliers use synthetic resveratrol as a natural resveratrol substitute for polygonum cuspidatum. The reason is the lower cost of synthetic resveratrol. If the supplier does not disclose the type of resveratrol contained in the product, you can assume that it is a synthetic variety.

Quercetin or no quercetin?

Quercetin is a powerful antioxidant in its own right, but it should not be combined with resveratrol or taken at least 8 hours to take resveratrol supplementation. The reason, recently discovered, is that quercetin prevents resveratrol metabolites from entering your bloodstream. Quercetin also lowers sirtuin, precisely the effect of resveratol. So many years ago it was assumed that adding quercetin was a good thing because the importance of metabolites was unknown. At that time it was assumed that metabolites were not responsible for the metabolic and epigenetic effects of resveratrol. Based on some well-known studies, we now know that most of the beneficial reactions of resveratrol are actually from these metabolites and later from independent resveratrol. This metabolite is a bioactive product of resveratrol fragments by liver and endothelial cells that cover the small intestine. By blocking these sulfates and quercetin glucordinates disrupt the ability of resveratrol to activate sirtuins, in particular SirT2, a gene called anti-aging, and block other signaling pathways through resveratrol that operate, and are responsible for many of the desired health effects of resveratrol. In addition, the half-life of metabolites is several hours while the free half-life of resveratrol is only about 12 minutes. In a 2009 study on the effects of resveratrol to induce the creation of hemoglobin cells in the blood of Thalasemmia patients, it was found that quercetin impedes resveratrol's ability to create new red blood cells. Quercetin also abolished the anti-inflammatory properties of resveratol in an informal trial of the effect of pallative resveratol on arthritis. There is no scientific justification for adding quercetin to resveratol supplementation. If one wants to take quercetin it is easily available as a low cost supplement that may be taken by itself.

Your provider's eligibility

The media coverage of the study shows the potential benefits of resveratrol have attracted a flood of new and clear resveratrol sellers that are undeniable to the market. These companies have no experience in producing food or health supplements, no scientific staff, laboratories or other technical resources, no standards of quality control and no history that can judge their reliability and integrity. Most of these companies use the word resveratrol form in their name and sell it only through the website. Lawyers for Dr Mehmet Oz and Oprah Winfrey have recently filed federal lawsuits against more than 50 of these companies for illegally using their trademarks and making false claims that their products have been verified by them recognizing their personality.

Your resveratol provider should be a manufacturer of only resveratrol resellers from unknown sources, it should have a history of at least ten years, preferably, from ethical business operations. It should offer a variety of products not just one or two almost identical products. Its product should have surpassed the recent assessment of the resveratrol brand by the Consumer Lab, and its website should provide an easy way to contact the company for any questions, complaints or requests for a refund. If a company offers a monthly recurring order program a clear and easy way to cancel your subscription should be offered. If the company's products are not available in brick and mortar stores such as GNC, The Vitamin Shop and other reputable sellers, they may be avoided. Anyone can sell products over the Internet but have products accepted by major Health and Supplements stores requiring liability insurance, comprehensive testing of product quality and inspection of the company and its principals.

The gold standard for manufacturers is for their products to win widespread acceptance by the medical and research community. Resveratrol is used in human trials at institutions such as the Albert Einstein School of Medicine and the NIH is the purest and most comprehensive supplement available to the public.


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