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Resveratrol - Decoding the Genetics of Aging

Over the past three decades, great strides have been made in anti-aging research. The end of the Human Genome project has enabled anti-aging scientists to begin to understand the genetics of aging. We have over 20,000 genes, and in this large group, scientists have isolated a set of genes that regulate aging. The basic fact that there are genes that regulate aging is one of the most influential findings of the 21st century. However, the discovery of longevity genes is solely for genetic decoding of aging. Scientists are now researching what these genes are and how they do it. What we do know about these genes is that, once activated, they can prolong life and delay the onset of age-related diseases such as diabetes, heart disease and cancer.

As scientists continue to interpret the genetics of aging, they have found that resveratrol, a compound in the skin of wine and red wine, can alter this longevity gene. Most studies on these long-term genes and the effects of resveratrol may be related to Dr. David Sinclair, a world-renowned geneticist. Sirtuins, a group of cellular enzymes, are at the core of Dr.'s research. Sinclair. We now know that sirtuin (pronounced lord-TOO-in), is a universal regulator of aging found in most living organisms from bacteria and yeast to humans.

According to Dr. Sinclair, sirtuin acts as a cell guard. They allow cells to survive and delay cell death. Every cell in your body has its own genetic code to reproduce itself. Sirtuins, like the silent caretakers, watch the cellular and spring overlap as actions to correct misinterpretations of the genetic code. However, over time, environmental pollution, dietary factors, and lifestyle issues add to the genetic damage and natural repair mechanisms soon. The result is damage to DNA that will have a ripple effect in subsequent cell duplication.

Think of it as a photocopy. If the copy machine works properly, the original document will produce a clean copy. However, if the photocopying machine is not maintained, it will produce bad results. If you continue to make poor copywriting, subsequent duplication will be degraded with each successive copy cycle.

Dr. Sinclair and his colleagues know that sirtuin can repair DNA damage to aging cells, but the question now is how to activate the sirtuin pathway. Dr. Sinclair tested tens of thousands of compounds and his first isolated sirtuin activator was resveratrol. In conjunction with the National Institutes of Health, he began testing his theory that resveratrol can activate longevity genes in laboratory animals.

In his landmark study, he used three groups of laboratory mice. One group of year-old laboratory mice were fed calories, high-fat diets, and supplemented with resveratrol. The second group was fed a high-fat, high-calorie diet but was not given a resveratrol supplement. The Third group had a normal diet and no resveratrol.

Mice on a high-fat diet without resveratrol soon became obese and began to die at an accelerated rate of heart disease and cancer. However, animals that are high in fat and supplemented with resveratrol are better. Blood tests reveal glucose and insulin levels in their blood, much lower than high-fat resveratrol mice, and resveratrol mice suffer from diabetes, heart disease and cancer.

Animals supplemented with resveratrol have more energy, run faster and with more resistance than high-fat groups without additional resveratrol. More importantly, more than one year after the experiment started the resveratrol group mortality was similar to that for animals on a normal diet. According to Dr. Sinclair, resveratrol has modified the most popular genetic pathways of aging. He commented at the end of the study; "I try not to make promises, but the data looks great, they surprise me."

In fact, the results have shocked the scientific community. Imagine a natural ingredient that activates a genetic defense mechanism that can compensate for the health effects of poor diet and other common diseases such as diabetes, heart disease and cancer.

Based on the success of the first study of resveratrol, Dr. Sinclair partnered with entrepreneur Christoph Westphal, another Harvard Ph.D., and together they raised tens of millions of dollars to create Sirtris Pharmaceuticals, a bio-tech company based in Cambridge Massachusetts. The ladies immediately put their version of resveratrol in a test in an FDA-approved study.

In a preliminary study, diabetics received daily doses of resveratrol or placebo. After 28 days, patients taking resveratrol showed better scores on the oral glucose tolerance test, which measures the body's ability to break down and use blood sugar. Patients taking placebo showed no improvement. The study also found that resveratrol appeared to lower glucose levels in diabetic patients.

It may take too long to call youth resveratrol, but pharmaceutical giant Glaxo Smith Kline recently bought Sirtris Pharmaceuticals and all rights to the reported resveratrol-based drug for $ 750 million were reported. Time will tell if resveratrol can slow down the aging process. However, further research continues to promise that someday there will be pills to treat aging diseases such as diabetes, heart disease, cancer and Alzheimer's disease.

Recent research into resveratrol confirms what Dr. Sinclair. In a recent study conducted at the College of Life Sciences, Chinese researchers studied the effect of resveratrol on Atherosclerosis, a progressive circulatory disease characterized by blockage or hardening of blood vessels caused by plaque accumulation. The results of their study show that resveratrol slows the progression of disease and improved blood vessel function by controlling melting and narrowing.

Scientists have found that resveratrol has a strong anti-inflammatory effect on the blood vessels, which many experts believe is a major catalyst for heart disease. In this study, resveratrol had a positive effect on blood pressure and reduced overall oxidative stress through its strong antioxidant properties. In addition, resveratrol inhibits LDL cholesterol modification and improves overall circulation. Research results on resveratrol show it has a positive effect on heart health.

Studies have shown that resveratrol has the potential to prevent cardiovascular disease and reduce inflammation throughout the cardiovascular system. Some studies show that resveratrol is effective in maintaining bone health and delaying the onset of osteoporosis. Most of these studies prove that laboratory animals supplemented with resveratrol have improved muscle strength and endurance, improved coordination and movement and reduced fat cells.

Recent studies have shown that resveratrol can be your brain's best friend. Researchers are studying the action of resveratrol as a potential therapeutic agent in the treatment of Alzheimer's disease. Several epidemiological studies show that moderate consumption of wine is associated with lower incidence of Alzheimer's disease. However, the exact molecular mechanism involved is still well defined until researchers investigate the action of resveratrol on amyloid B, a bio marker for Alzheimer's disease.

They found that resveratrol did not inhibit Amyloid B. B production.

Resveratrol is a molecule produced by plants in response to stress. By producing resveratrol, this plant can deal with many negative factors in the environment. Resveratrol is probably one of the greatest discoveries of our time. Many studies confirm that resveratrol can improve cardiovascular function and offset the effects of dietary health and poor lifestyle choices. Overall, the health benefits of resveratrol age closely mimic those previously associated with a strict calorie restriction diet - raising hopes for a simple and easy way to help fight age-related decline.

Add resveratrol to your diet routine. I recommend 2 capsules daily from Resveratrol Best Doctor's, a high-quality resveratrol extract in polyphenol based on mixed plants, which has been shown to enhance resveratrol action. To order Doctor's best resveratrol, call (866) -866-3320.

(1): "Resveratrol promotes release of amyloid-beta peptides of Alzheimer's disease." September 13, 2009 http://www.ncbi.nlm.nih.gov/pubmed/16162502.



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